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2gp3
From Proteopedia
| 2gp3, resolution 2.35Å () | |||||||||
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| Sites: | , , and | ||||||||
| Ligands: | , | ||||||||
| Gene: | JMJD2A (Homo sapiens) | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Crystal structure of the catalytic core comain of jmjd2a
Posttranslational modifications of histones regulate chromatin structure and gene expression. Histone demethylases, members of a newly emerging transcription-factor family, remove methyl groups from the lysine residues of the histone tails and thereby regulate the transcriptional activity of target genes. JmjC-domain-containing proteins have been predicted to be demethylases. For example, the JmjC-containing protein JMJD2A has been characterized as a H3-K9me3- and H3-K36me3-specific demethylase. Here, structures of the catalytic-core domain of JMJD2A with and without alpha-ketoglutarate in the presence of Fe2+ have been determined by X-ray crystallography. The structure of the core domain, consisting of the JmjN domain, the JmjC domain, the C-terminal domain, and a zinc-finger motif, revealed the unique elements that form a potential substrate binding pocket. Sited-directed mutagenesis in conjunction with demethylase activity assays allowed us to propose a molecular model for substrate selection by the JMJD2 histone demethylase family.
Structural insights into histone demethylation by JMJD2 family members., Chen Z, Zang J, Whetstine J, Hong X, Davrazou F, Kutateladze TG, Simpson M, Mao Q, Pan CH, Dai S, Hagman J, Hansen K, Shi Y, Zhang G, Cell. 2006 May 19;125(4):691-702. Epub 2006 May 4. PMID:16677698
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2GP3 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Chen Z, Zang J, Whetstine J, Hong X, Davrazou F, Kutateladze TG, Simpson M, Mao Q, Pan CH, Dai S, Hagman J, Hansen K, Shi Y, Zhang G. Structural insights into histone demethylation by JMJD2 family members. Cell. 2006 May 19;125(4):691-702. Epub 2006 May 4. PMID:16677698 doi:10.1016/j.cell.2006.04.024
Page seeded by OCA on Wed Oct 14 20:09:21 2009
Categories: Homo sapiens | Chen, Z. | Dai, S. | Davrazou, F. | Hagman, J. | Hong, X. | Kutateladze, T G. | Shi, Y. | Simpson, M. | Whetstine, J. | Zang, J. | Zhang, G. | Beta barrel | Metal binding protein | Zinc finger
