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2gow
From Proteopedia
| 2gow, 20 NMR models () | |||||||||
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| Gene: | UBL3 (Homo sapiens) | ||||||||
| Domains: | NTGP5 | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB, TOPSAN | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Solution structure of BC059385 from Homo sapiens
The protein Bc059385, whose solution structure is reported here, is the human representative of a recently identified family of membrane-anchored ubiquitin-fold (MUB) proteins. Analysis of their similarity to ubiquitin indicates that homologous amino acid residues in MUBs form a hydrophobic surface very similar to the recognition patch surrounding Ile-44 in ubiquitin. This suggests that MUBs may interact with proteins containing an alpha-helical motif similar to those of some ubiquitin binding domains. A disordered loop common to MUBs may also provide a second protein interaction site. From the available data, it is probable that this protein is prenylated and associated with the membrane. With <20% identity to ubiquitin, the MUB family further expands the sequence space that maps to the beta-grasp fold, and adds membrane localization to its list of functional roles.
Solution structure of a membrane-anchored ubiquitin-fold (MUB) protein from Homo sapiens., de la Cruz NB, Peterson FC, Lytle BL, Volkman BF, Protein Sci. 2007 Jul;16(7):1479-84. Epub 2007 Jun 13. PMID:17567738
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2GOW is a 1 chain structure of sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- de la Cruz NB, Peterson FC, Lytle BL, Volkman BF. Solution structure of a membrane-anchored ubiquitin-fold (MUB) protein from Homo sapiens. Protein Sci. 2007 Jul;16(7):1479-84. Epub 2007 Jun 13. PMID:17567738 doi:10.1110/ps.072834007
Page seeded by OCA on Mon Jan 18 10:31:28 2010
