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2gli
From Proteopedia
FIVE-FINGER GLI/DNA COMPLEX
Zinc finger proteins, of the type first discovered in transcription factor IIIA (TFIIIA), are one of the largest and most important families of DNA-binding proteins. The crystal structure of a complex containing the five Zn fingers from the human GLI oncogene and a high-affinity DNA binding site has been determined at 2.6 A resolution. Finger one does not contact the DNA. Fingers two through five bind in the major groove and wrap around the DNA, but lack the simple, strictly periodic arrangement observed in the Zif268 complex. Fingers four and five of GLI make extensive base contacts in a conserved nine base-pair region, and this section of the DNA has a conformation intermediate between B-DNA and A-DNA. Analyzing the GLI complex and comparing it with Zif268 offers new perspectives on Zn finger-DNA recognition.
Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers., Pavletich NP, Pabo CO, Science. 1993 Sep 24;261(5129):1701-7. PMID:8378770
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2GLI is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Pavletich NP, Pabo CO. Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers. Science. 1993 Sep 24;261(5129):1701-7. PMID:8378770
Page seeded by OCA on Tue Feb 17 11:06:20 2009
