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From Proteopedia

2gfu, 20 NMR models ()
Domains:	PWWP
Structural annotation: Resources: InterPro : Ipr000432, Ipr000313, Ipr007861, Ipr007696, Ipr007860, Ipr007695, Ipr015536 Pfam : PF00855 UniProt : P52701
Functional annotation: Resources: GeneCard : MSH6 Cellular component: MutSalpha complex nucleus nuclear chromatin Biological process: DNA damage response, signal transduction resulting in induction of apoptosis negative regulation of DNA recombination isotype switching DNA repair somatic hypermutation of immunoglobulin genes somatic recombination of immunoglobulin gene segments response to UV base-excision repair mismatch repair induction of apoptosis by intracellular signals response to DNA damage stimulus determination of adult life span Molecular function: nucleotide binding single guanine insertion binding double-stranded DNA binding ATPase activity guanine/thymine mispair binding mispaired DNA binding ADP binding four-way junction DNA binding oxidized purine DNA binding damaged DNA binding single thymine insertion binding chromatin binding protein binding protein homodimerization activity MutLalpha complex binding dinucleotide insertion or deletion binding DNA binding magnesium ion binding ATP binding mismatched DNA binding purine-specific mismatch base pair DNA N-glycosylase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

NMR solution structure of the PWWP domain of Mismatch repair protein hMSH6

About this Structure

2GFU is a 1 chain structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Page seeded by OCA on Mon Feb 16 14:30:19 2009