2fw4

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2fw4, resolution 2.00Å ()
Ligands: ,
Activity: Carbonate dehydratase, with EC number 4.2.1.1
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Contents

Carbonic anhydrase activators. The first X-ray crystallographic study of an activator of isoform I, structure with L-histidine.

Publication Abstract from PubMed

The X-ray crystallographic structure for the adduct of an activator with human carbonic anhydrase isozyme I (hCA I) is reported. L-Histidine binds deep within the enzyme active site, participating in a network of hydrogen bonds involving its carboxylate moiety and the zinc-bound water molecule, as well as the imidazole of His200, being in van der Waals contacts with Thr199, His200, His64, and His67. This binding is very different from that to the other major cytosolic isozyme hCA II.

Carbonic anhydrase activators: the first X-ray crystallographic study of an adduct of isoform I., Temperini C, Scozzafava A, Supuran CT, Bioorg Med Chem Lett. 2006 Oct 1;16(19):5152-6. Epub 2006 Jul 25. PMID:16870440

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

2fw4 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Temperini C, Scozzafava A, Supuran CT. Carbonic anhydrase activators: the first X-ray crystallographic study of an adduct of isoform I. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5152-6. Epub 2006 Jul 25. PMID:16870440 doi:http://dx.doi.org/10.1016/j.bmcl.2006.07.021

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