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2f8x
From Proteopedia
Crystal structure of activated Notch, CSL and MAML on HES-1 promoter DNA sequence
Notch receptors transduce essential developmental signals between neighboring cells by forming a complex that leads to transcription of target genes upon activation. We report here the crystal structure of a Notch transcriptional activation complex containing the ankyrin domain of human Notch1 (ANK), the transcription factor CSL on cognate DNA, and a polypeptide from the coactivator Mastermind-like-1 (MAML-1). Together, CSL and ANK create a groove to bind the MAML-1 polypeptide as a kinked, 70 A helix. The composite binding surface likely restricts the recruitment of MAML proteins to promoters on which Notch:CSL complexes have been preassembled, ensuring tight transcriptional control of Notch target genes.
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes., Nam Y, Sliz P, Song L, Aster JC, Blacklow SC, Cell. 2006 Mar 10;124(5):973-83. PMID:16530044
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2F8X is a 5 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Nam Y, Sliz P, Song L, Aster JC, Blacklow SC. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell. 2006 Mar 10;124(5):973-83. PMID:16530044 doi:10.1016/j.cell.2005.12.037
Page seeded by OCA on Tue Feb 17 10:39:41 2009
Categories: Homo sapiens | Blacklow, S C. | Nam, Y. | Sliz, P. | Ankyrin repeat | Csl | Hes-1 | Mastermind | Notch | Rel-homology region
