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2f12
From Proteopedia
| 2f12, resolution 2.27Å () | |||||||||
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| Ligands: | , | ||||||||
| Activity: | Exo-alpha-sialidase, with EC number 3.2.1.18 | ||||||||
| Related: | 1snt, 1so7, 1vcu, 2f0z, 2f10, 2f11, 2f13, 2f24, 2f25, 2f26, 2f27, 2f28, 2f29 | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
Crystal Structure of the Human Sialidase Neu2 in Complex with 3- hydroxypropyl ether mimetic Inhibitor
With the global spread of the pandemic H1N1 and the ongoing pandemic potential of the H5N1 subtype, the influenza virus represents one of the most alarming viruses spreading worldwide. The influenza virus sialidase is an effective drug target, and a number of inhibitors are clinically effective against the virus (zanamivir, oseltamivir, peramivir). Here we report structural and biochemical studies of the human cytosolic sialidase Neu2 with influenza virus sialidase-targeting drugs and related compounds.
Complexity in influenza virus targeted drug design: interaction with human sialidases., Chavas LM, Kato R, Suzuki N, von Itzstein M, Mann MC, Thomson RJ, Dyason JC, McKimm-Breschkin J, Fusi P, Tringali C, Venerando B, Tettamanti G, Monti E, Wakatsuki S, J Med Chem. 2010 Apr 8;53(7):2998-3002. PMID:020222714
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2f12 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Chavas LM, Kato R, Suzuki N, von Itzstein M, Mann MC, Thomson RJ, Dyason JC, McKimm-Breschkin J, Fusi P, Tringali C, Venerando B, Tettamanti G, Monti E, Wakatsuki S. Complexity in influenza virus targeted drug design: interaction with human sialidases. J Med Chem. 2010 Apr 8;53(7):2998-3002. PMID:20222714 doi:10.1021/jm100078r
