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2e9s
From Proteopedia
| 2e9s, resolution 1.78Å () | |||||||||
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| Sites: | , , , , and | ||||||||
| Ligands: | , , | ||||||||
| Gene: | RAB6B (Homo sapiens) | ||||||||
| Domains: | Rab6 | ||||||||
| Related: | 2fe4, 2ffq | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
human neuronal Rab6B in three intermediate forms
The Rab small G-protein family plays important roles in eukaryotes as regulators of vesicle traffic. In Rab proteins, the hydrolysis of GTP to GDP is coupled with association with and dissociation from membranes. Conformational changes related to their different nucleotide states determine their effector specificity. The crystal structure of human neuronal Rab6B was solved in its 'inactive' (with bound MgGDP) and 'active' (MgGTPgammaS-bound) forms to 2.3 and 1.8 A, respectively. Both crystallized in space group P2(1)2(1)2(1), with similar unit-cell parameters, allowing the comparison of both structures without packing artifacts. Conformational changes between the inactive GDP and active GTP-like state are observed mainly in the switch I and switch II regions, confirming their role as a molecular switch. Compared with other Rab proteins, additional changes are observed in the Rab6 subfamily-specific RabSF3 region that might contribute to the specificity of Rab6 for its different effector proteins.
The structure of human neuronal Rab6B in the active and inactive form., Garcia-Saez I, Tcherniuk S, Kozielski F, Acta Crystallogr D Biol Crystallogr. 2006 Jul;62(Pt 7):725-33. Epub 2006, Jun 20. PMID:16790928
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2E9S is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Garcia-Saez I, Tcherniuk S, Kozielski F. The structure of human neuronal Rab6B in the active and inactive form. Acta Crystallogr D Biol Crystallogr. 2006 Jul;62(Pt 7):725-33. Epub 2006, Jun 20. PMID:16790928 doi:10.1107/S0907444906015319
Page seeded by OCA on Tue Feb 17 15:56:45 2009
