2d9g

Structural highlights

Function

[YAF2_HUMAN] Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling.^{[1] [2] [3]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC. Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1. Nucleic Acids Res. 1997 Feb 15;25(4):843-9. PMID:9016636
2. ↑ Bannasch D, Madge B, Schwab M. Functional interaction of Yaf2 with the central region of MycN. Oncogene. 2001 Sep 13;20(41):5913-9. PMID:11593398 doi:http://dx.doi.org/10.1038/sj.onc.1204747
3. ↑ Madge B, Geisen C, Moroy T, Schwab M. Yaf2 inhibits Myc biological function. Cancer Lett. 2003 Apr 25;193(2):171-6. PMID:12706874