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2cyx
From Proteopedia
| 2cyx, resolution 2.56Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene: | UBE2G2 (Homo sapiens) | ||||||||
| Activity: | Ubiquitin--protein ligase, with EC number 6.3.2.19 | ||||||||
| Domains: | UBCc | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB, TOPSAN | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)
The human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7) is involved in protein degradation, including a process known as endoplasmic reticulum-associated degradation (ERAD). The crystal structure of human UBE2G2/UBC7 was solved at 2.56 angstroms resolution. The UBE2G2 structure comprises a single domain consisting of an antiparallel beta-sheet with four strands, five alpha-helices and two 3(10)-helices. Structural comparison of human UBE2G2 with yeast Ubc7 indicated that the overall structures are similar except for the long loop region and the C-terminal helix. Superimposition of UBE2G2 on UbcH7 in a c-Cbl-UbcH7-ZAP70 ternary complex suggested that the two loop regions of UBE2G2 interact with the RING domain in a similar way to UbcH7. In addition, the extra loop region of UBE2G2 may interact with the RING domain or its neighbouring region and may be involved in the binding specificity and stability.
Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)., Arai R, Yoshikawa S, Murayama K, Imai Y, Takahashi R, Shirouzu M, Yokoyama S, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt, 4):330-4. Epub 2006 Mar 25. PMID:16582478
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2CYX is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Arai R, Yoshikawa S, Murayama K, Imai Y, Takahashi R, Shirouzu M, Yokoyama S. Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7). Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt, 4):330-4. Epub 2006 Mar 25. PMID:16582478 doi:10.1107/S1744309106009006
Page seeded by OCA on Tue Feb 17 14:52:47 2009
Categories: Homo sapiens | Ubiquitin--protein ligase | Arai, R. | Imai, Y. | Murayama, K. | RSGI, RIKEN Structural Genomics/Proteomics Initiative. | Shirouzu, M. | Takahashi, R. | Yokoyama, S. | Yoshikawa, S. | Ligase | National project on protein structural and functional analyse | Nppsfa | Riken structural genomics/proteomics initiative | Rsgi | Structural genomic | Ubl conjugation pathway
