2cuf

Structural highlights

Function

[HMBX1_HUMAN] Transcription factor. Isoform 1 acts as a transcriptional repressor. Isoform 4 has very low activity as a transcriptional repressor.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Chen S, Saiyin H, Zeng X, Xi J, Liu X, Li X, Yu L. Isolation and functional analysis of human HMBOX1, a homeobox containing protein with transcriptional repressor activity. Cytogenet Genome Res. 2006;114(2):131-6. PMID:16825764 doi:http://dx.doi.org/10.1159/000093328
2. ↑ Zhang M, Chen S, Li Q, Ling Y, Zhang J, Yu L. Characterization of a novel human HMBOX1 splicing variant lacking the homeodomain and with attenuated transcription repressor activity. Mol Biol Rep. 2010 Jul;37(6):2767-72. doi: 10.1007/s11033-009-9815-9. Epub 2009, Sep 15. PMID:19757162 doi:http://dx.doi.org/10.1007/s11033-009-9815-9