Structural highlights
Function
[CE350_HUMAN] Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity.[1] [2] [3] [4] [5]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Patel H, Truant R, Rachubinski RA, Capone JP. Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350. J Cell Sci. 2005 Jan 1;118(Pt 1):175-86. PMID:15615782 doi:http://dx.doi.org/10.1242/jcs.01600
- ↑ Yan X, Habedanck R, Nigg EA. A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring. Mol Biol Cell. 2006 Feb;17(2):634-44. Epub 2005 Nov 28. PMID:16314388 doi:E05-08-0810
- ↑ Hoppeler-Lebel A, Celati C, Bellett G, Mogensen MM, Klein-Hitpass L, Bornens M, Tassin AM. Centrosomal CAP350 protein stabilises microtubules associated with the Golgi complex. J Cell Sci. 2007 Sep 15;120(Pt 18):3299-308. PMID:17878239 doi:http://dx.doi.org/10.1242/jcs.013102
- ↑ Lelievre H, Chevrier V, Tassin AM, Birnbaum D. Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cgamma at the centrosome. Mol Cancer. 2008 Apr 15;7:30. doi: 10.1186/1476-4598-7-30. PMID:18412956 doi:http://dx.doi.org/10.1186/1476-4598-7-30
- ↑ Le Clech M. Role of CAP350 in centriolar tubule stability and centriole assembly. PLoS One. 2008;3(12):e3855. doi: 10.1371/journal.pone.0003855. Epub 2008 Dec 4. PMID:19052644 doi:http://dx.doi.org/10.1371/journal.pone.0003855
