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2bzf
From Proteopedia
| 2bzf, resolution 2.87Å () | |||||||||||
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| Domains: | BAF | ||||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||
STRUCTURAL BASIS FOR DNA BRIDGING BY BARRIER-TO-AUTOINTEGRATION FACTOR (BAF)
The ability of barrier-to-autointegration factor (BAF) to bind and bridge DNA in a sequence-independent manner is crucial for its role in retroviral integration and a variety of cellular processes. To better understand this behavior, we solved the crystal structure of BAF bound to DNA. The structure reveals that BAF bridges DNA using two pairs of helix-hairpin-helix motifs located on opposite surfaces of the BAF dimer without changing its conformation.
Structural basis for DNA bridging by barrier-to-autointegration factor., Bradley CM, Ronning DR, Ghirlando R, Craigie R, Dyda F, Nat Struct Mol Biol. 2005 Oct;12(10):935-6. Epub 2005 Sep 11. PMID:16155580
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2BZF is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Bradley CM, Ronning DR, Ghirlando R, Craigie R, Dyda F. Structural basis for DNA bridging by barrier-to-autointegration factor. Nat Struct Mol Biol. 2005 Oct;12(10):935-6. Epub 2005 Sep 11. PMID:16155580 doi:10.1038/nsmb989
Page seeded by OCA on Tue Feb 17 13:44:05 2009
