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2boc
From Proteopedia
| 2boc, resolution 3.01Å () | |||||||||
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| Sites: | , , , and | ||||||||
| Ligands: | , , | ||||||||
| Related: | 1bl8, 1f6g, 1j95, 1jq1, 1jq2, 1jvm, 1k4c, 1k4d, 1r3i, 1r3j, 1r3k, 1r3l, 1s5h, 2bob | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
POTASSIUM CHANNEL KCSA-FAB COMPLEX IN THALLIUM WITH TETRAETHYLARSONIUM (TEAS)
Potassium channels catalyze the selective transfer of potassium across the cell membrane and are essential for setting the resting potential in cells, controlling heart rate and modulating the firing pattern in neurons. Tetraethylammonium (TEA) blocks ion conduction through potassium channels in a voltage-dependent manner from both sides of the membrane. Here we show the structural basis of TEA blockade by cocrystallizing the prokaryotic potassium channel KcsA with two selective TEA analogs. TEA binding at both sites alters ion occupancy in the selectivity filter; these findings underlie the mutual destabilization and voltage-dependence of TEA blockade. We propose that TEA blocks potassium channels by acting as a potassium analog at the dehydration transition step during permeation.
Structural basis of TEA blockade in a model potassium channel., Lenaeus MJ, Vamvouka M, Focia PJ, Gross A, Nat Struct Mol Biol. 2005 May;12(5):454-9. Epub 2005 Apr 24. PMID:15852022
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2boc is a 3 chain structure of Ion channels with sequence from Mus musculus and Streptomyces lividans. Full crystallographic information is available from OCA.
See Also
Reference
- Lenaeus MJ, Vamvouka M, Focia PJ, Gross A. Structural basis of TEA blockade in a model potassium channel. Nat Struct Mol Biol. 2005 May;12(5):454-9. Epub 2005 Apr 24. PMID:15852022 doi:10.1038/nsmb929
