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2bat

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2bat, resolution 2.00Å ()
Ligands: , , , , ,
Non-Standard Residues:
Activity: Exo-alpha-sialidase, with EC number 3.2.1.18
Related: 1nn2
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Contents

THE STRUCTURE OF THE COMPLEX BETWEEN INFLUENZA VIRUS NEURAMINIDASE AND SIALIC ACID, THE VIRAL RECEPTOR

Publication Abstract from PubMed

Crystallographic studies of neuraminidase-sialic acid complexes indicate that sialic acid is distorted on binding the enzyme. Three arginine residues on the enzyme interact with the carboxylate group of the sugar which is observed to be equatorial to the saccharide ring as a consequence of its distorted geometry. The glycosidic oxygen is positioned within hydrogen-bonding distance of Asp-151, implicating this residue in catalysis.

The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor., Varghese JN, McKimm-Breschkin JL, Caldwell JB, Kortt AA, Colman PM, Proteins. 1992 Nov;14(3):327-32. PMID:1438172

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

2bat is a 1 chain structure with sequence from Viruses. The May 2009 RCSB PDB Molecule of the Month feature on Influenza Neuraminidase by David Goodsell is 10.2210/rcsb_pdb/mom_2009_5. Full crystallographic information is available from OCA.

See Also

Reference

  • Varghese JN, McKimm-Breschkin JL, Caldwell JB, Kortt AA, Colman PM. The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor. Proteins. 1992 Nov;14(3):327-32. PMID:1438172 doi:http://dx.doi.org/10.1002/prot.340140302

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