2b9z
From Proteopedia
Solution structure of FHV B2, a viral suppressor of RNAi
Structural highlights
FunctionB2_FHV Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response.[1] [2] Publication Abstract from PubMedWe report the structure of the flock house virus B2 protein, a potent suppressor of RNA interference (RNAi) in animals and plants. The B2 protein is a homodimer in solution and contains three alpha-helices per monomer. Chemical shift perturbation shows that an antiparallel arrangement of helices (alpha2/alpha2') forms an elongated binding interface with double-stranded RNA (dsRNA). This implies a novel mode of dsRNA recognition and provides insights into the mechanism of RNAi suppression by B2. The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition.,Lingel A, Simon B, Izaurralde E, Sattler M EMBO Rep. 2005 Dec;6(12):1149-55. PMID:16270100[3] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also
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