2apu

From Proteopedia

Jump to: navigation, search
Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.


2apu ()
Resources: FirstGlance, PDBsum
Coordinates: save as pdb, mmCIF, xml



A MODEL FOR AMYLOID-LIKE FIBRILS OF RIBONUCLEASE A WITH THREE-DIMENSIONAL DOMAIN-SWAPPED, NATIVE-LIKE STRUCTURE.

Publication Abstract from PubMed

Amyloid or amyloid-like fibrils are elongated, insoluble protein aggregates, formed in vivo in association with neurodegenerative diseases or in vitro from soluble native proteins, respectively. The underlying structure of the fibrillar or 'cross-beta' state has presented long-standing, fundamental puzzles of protein structure. These include whether fibril-forming proteins have two structurally distinct stable states, native and fibrillar, and whether all or only part of the native protein refolds as it converts to the fibrillar state. Here we show that a designed amyloid-like fibril of the well-characterized enzyme RNase A contains native-like molecules capable of enzymatic activity. In addition, these functional molecular units are formed from a core RNase A domain and a swapped complementary domain. These findings are consistent with the zipper-spine model in which a cross-beta spine is decorated with three-dimensional domain-swapped functional units, retaining native-like structure.

Amyloid-like fibrils of ribonuclease A with three-dimensional domain-swapped and native-like structure., Sambashivan S, Liu Y, Sawaya MR, Gingery M, Eisenberg D, Nature. 2005 Sep 8;437(7056):266-9. PMID:16148936

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Reference

  • Sambashivan S, Liu Y, Sawaya MR, Gingery M, Eisenberg D. Amyloid-like fibrils of ribonuclease A with three-dimensional domain-swapped and native-like structure. Nature. 2005 Sep 8;437(7056):266-9. PMID:16148936 doi:10.1038/nature03916

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools