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2ajf
From Proteopedia
| 2ajf, resolution 2.90Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Sites: | , , , , , , , , , , , , , , and | ||||||||
| Ligands: | , , , | ||||||||
| Gene: | ACE2 (Homo sapiens), S (SARS coronavirus) | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Structure of SARS coronavirus spike receptor-binding domain complexed with its receptor
The spike protein (S) of SARS coronavirus (SARS-CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction. The crystal structure at 2.9 angstrom resolution of the RBD bound with the peptidase domain of human ACE2 shows that the RBD presents a gently concave surface, which cradles the N-terminal lobe of the peptidase. The atomic details at the interface between the two proteins clarify the importance of residue changes that facilitate efficient cross-species infection and human-to-human transmission. The structure of the RBD suggests ways to make truncated disulfide-stabilized RBD variants for use in the design of coronavirus vaccines.
Structure of SARS coronavirus spike receptor-binding domain complexed with receptor., Li F, Li W, Farzan M, Harrison SC, Science. 2005 Sep 16;309(5742):1864-8. PMID:16166518
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2AJF is a 4 chains structure of sequences from Homo sapiens and Sars coronavirus. Full crystallographic information is available from OCA.
See Angiotensin-Converting Enzyme for additional structural information.
Reference
- Li F, Li W, Farzan M, Harrison SC. Structure of SARS coronavirus spike receptor-binding domain complexed with receptor. Science. 2005 Sep 16;309(5742):1864-8. PMID:16166518 doi:309/5742/1864
Page seeded by OCA on Mon Feb 16 12:24:39 2009
