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From Proteopedia

1zys, resolution 1.70Å ()
Ligands:	,
Gene:	CHEK1, CHK1 (Homo sapiens)
Activity:	Non-specific serine/threonine protein kinase, with EC number 2.7.11.1
Domains:	S_TKc, S_TKc
Related:	1nvq, 1nvr, 1nvs
Structural annotation: Resources: CATH : 1Zysa02, 1Zysa01 InterPro : Ipr002290, Ipr015729, Ipr011009, Ipr008271, Ipr000719 Pfam : PF00069 UniProt : O14757
Functional annotation: Resources: GeneCard : CHEK1 Cellular component: replication fork nucleus condensed nuclear chromosome cytoplasm Biological process: DNA damage checkpoint regulation of cyclin-dependent protein kinase activity protein amino acid phosphorylation G2/M transition of mitotic cell cycle negative regulation of cell proliferation gamete generation response to DNA damage stimulus meiotic recombination cell cycle DNA repair Molecular function: protein serine/threonine kinase activity transferase activity kinase activity ATP binding nucleotide binding protein binding protein kinase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

Co-crystal structure of Checkpoint Kinase Chk1 with a pyrrolo-pyridine inhibitor

About this Structure

1ZYS is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Page seeded by OCA on Wed Feb 18 06:58:49 2009