Structural highlights
Function
TATD_ECOLI Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Although TatD is not required for export activity, it is a central component of a quality control system that is linked to the Tat translocation system. May act by degrading wild-type pre-protein molecules that are misfolded. Shows magnesium-dependent DNase activity.[1] [2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T. TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export. J Biol Chem. 2000 Jun 2;275(22):16717-22. PMID:10747959 doi:10.1074/jbc.M000800200
- ↑ Matos CF, Di Cola A, Robinson C. TatD is a central component of a Tat translocon-initiated quality control system for exported FeS proteins in Escherichia coli. EMBO Rep. 2009 May;10(5):474-9. doi: 10.1038/embor.2009.34. Epub 2009 Apr 3. PMID:19343049 doi:10.1038/embor.2009.34
