1xsl

From Proteopedia

Jump to: navigation, search


1xsl, resolution 2.30Å ()
Ligands: , ,
Gene: POLL (Homo sapiens)
Activity: DNA-directed DNA polymerase, with EC number 2.7.7.7
Related: 1xsn, 1xsp
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Contents

Crystal Structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap

Publication Abstract from PubMed

Pol lambda is a family X member believed to fill short gaps during DNA repair. Here we report crystal structures of Pol lambda representing three steps in filling a single-nucleotide gap. These structures indicate that, unlike other DNA polymerases, Pol lambda does not undergo large subdomain movements during catalysis, and they provide a clear characterization of the geometry and stereochemistry of the in-line nucleotidyl transfer reaction.

A closed conformation for the Pol lambda catalytic cycle., Garcia-Diaz M, Bebenek K, Krahn JM, Kunkel TA, Pedersen LC, Nat Struct Mol Biol. 2005 Jan;12(1):97-8. Epub 2004 Dec 19. PMID:15608652

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1xsl is a 16 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Garcia-Diaz M, Bebenek K, Krahn JM, Kunkel TA, Pedersen LC. A closed conformation for the Pol lambda catalytic cycle. Nat Struct Mol Biol. 2005 Jan;12(1):97-8. Epub 2004 Dec 19. PMID:15608652 doi:http://dx.doi.org/10.1038/nsmb876

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools