First time at Proteopedia? Click on the green links: they change the 3D image. Click and drag the molecules. Proteopedia is a 3D, interactive encyclopedia of proteins, RNA, DNA and other molecules. With a free user account, you can edit pages in Proteopedia. Visit the Main Page to learn more.
1xqg
From Proteopedia
| 1xqg, resolution 3.10Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene: | SERPINB5, PI5 (Homo sapiens) | ||||||||
| Domains: | maspin_like | ||||||||
| Related: | 1xqj | ||||||||
| |||||||||
| |||||||||
| |||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
3.10 A crystal structure of maspin, Space group P 4 21 2
Maspin, a member of the serpin superfamily, has tumor suppressing activity against breast and prostate cancer. Maspin inhibits tumor growth by blocking cell invasion, and its reactive center loop (RCL) is thought to mediate this activity. To understand this function on the molecular level, we have solved the three-dimensional structure of Maspin to 3.1 A resolution. The molecular structure shows the characteristic features of the serpin fold, but the RCL of Maspin is unique in length, composition, and placement. Although the RCL of Maspin is accessible and cleavable by some proteinases, it functions in the uncleaved, constrained conformation observed here. These structural results will contribute to our understanding of the mechanism by which Maspin suppresses tumors.
Crystal structure of human maspin, a serpin with antitumor properties: reactive center loop of maspin is exposed but constrained., Al-Ayyoubi M, Gettins PG, Volz K, J Biol Chem. 2004 Dec 31;279(53):55540-4. Epub 2004 Oct 22. PMID:15501821
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1XQG is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Al-Ayyoubi M, Gettins PG, Volz K. Crystal structure of human maspin, a serpin with antitumor properties: reactive center loop of maspin is exposed but constrained. J Biol Chem. 2004 Dec 31;279(53):55540-4. Epub 2004 Oct 22. PMID:15501821 doi:10.1074/jbc.M409957200
Page seeded by OCA on Wed Feb 18 00:42:53 2009
