First time at Proteopedia? Click on the green links: they change the 3D image. Click and drag the molecules. Proteopedia is a 3D, interactive encyclopedia of proteins, RNA, DNA and other molecules. With a free user account, you can edit pages in Proteopedia. Visit the Main Page to learn more.
1xox
From Proteopedia
SOLUTION STRUCTURE OF HUMAN SURVIVIN
NMR studies of the antiapoptotic protein survivin have been used to determine the homodimer interface of the protein in solution and to identify residues of the protein that interact with Smac/Diablo. In solution, survivin(1-120) forms a bow-tie-shaped dimer whose interface is composed of its N-terminal residues as well as residues connecting its BIR domain to the C-terminal alpha helix. The solution structure resolves the controversy regarding the two possible dimer interfaces for survivin observed in X-ray crystal structures. The structural basis for the interaction between survivin and Smac/Diablo was also investigated. When Smac/Diablo or N-terminal Smac/Diablo peptide analogues are added to a solution of survivin, specific residues near alpha4 and beta3 are perturbed. NMR experiments indicate that the peptides bind across the third beta-strand of survivin in a manner similar to the way Smac/Diablo peptides bind to the BIR3 domain of X-linked IAP (XIAP).
Solution structure of human survivin and its binding interface with Smac/Diablo., Sun C, Nettesheim D, Liu Z, Olejniczak ET, Biochemistry. 2005 Jan 11;44(1):11-7. PMID:15628841
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1XOX is a 2 chains structure of sequences from Homo sapiens. Full experimental information is available from OCA.
Reference
- Sun C, Nettesheim D, Liu Z, Olejniczak ET. Solution structure of human survivin and its binding interface with Smac/Diablo. Biochemistry. 2005 Jan 11;44(1):11-7. PMID:15628841 doi:10.1021/bi0485171
Page seeded by OCA on Tue Feb 17 06:21:37 2009
