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Structural highlights

Function

SABP2_TOBAC Required to convert methyl salicylate (MeSA) to salicylic acid (SA) as part of the signal transduction pathways that activate systemic acquired resistance in systemic tissue. MeSA is believed to be an inactive form that needs to be demethylated to exert a biological effect. Also able to catalyze the conversion of acibenzolar-S-methyl into acibenzolar to induce systemic acquired resistance.^{[1] [2] [3] [4] [5] [6]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Kumar D, Klessig DF. High-affinity salicylic acid-binding protein 2 is required for plant innate immunity and has salicylic acid-stimulated lipase activity. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):16101-6. Epub 2003 Dec 12. PMID:14673096 doi:http://dx.doi.org/10.1073/pnas.0307162100
2. ↑ Forouhar F, Yang Y, Kumar D, Chen Y, Fridman E, Park SW, Chiang Y, Acton TB, Montelione GT, Pichersky E, Klessig DF, Tong L. Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1773-8. Epub 2005 Jan 24. PMID:15668381
3. ↑ Park SW, Kaimoyo E, Kumar D, Mosher S, Klessig DF. Methyl salicylate is a critical mobile signal for plant systemic acquired resistance. Science. 2007 Oct 5;318(5847):113-6. PMID:17916738 doi:http://dx.doi.org/10.1126/science.1147113
4. ↑ Park SW, Liu PP, Forouhar F, Vlot AC, Tong L, Tietjen K, Klessig DF. Use of a synthetic salicylic acid analog to investigate the roles of methyl salicylate and its esterases in plant disease resistance. J Biol Chem. 2009 Mar 13;284(11):7307-17. doi: 10.1074/jbc.M807968200. Epub 2009 , Jan 8. PMID:19131332 doi:http://dx.doi.org/10.1074/jbc.M807968200
5. ↑ Tripathi D, Jiang YL, Kumar D. SABP2, a methyl salicylate esterase is required for the systemic acquired resistance induced by acibenzolar-S-methyl in plants. FEBS Lett. 2010 Aug 4;584(15):3458-63. doi: 10.1016/j.febslet.2010.06.046. Epub, 2010 Jul 14. PMID:20621100 doi:http://dx.doi.org/10.1016/j.febslet.2010.06.046
6. ↑ Padhi SK, Fujii R, Legatt GA, Fossum SL, Berchtold R, Kazlauskas RJ. Switching from an esterase to a hydroxynitrile lyase mechanism requires only two amino acid substitutions. Chem Biol. 2010 Aug 27;17(8):863-71. doi: 10.1016/j.chembiol.2010.06.013. PMID:20797615 doi:http://dx.doi.org/10.1016/j.chembiol.2010.06.013