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1wvo
From Proteopedia
| 1wvo, 20 NMR models () | |||||||||
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| Domains: | SAF | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB, TOPSAN | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Solution structure of RSGI RUH-029, an antifreeze protein like domain in human N-acetylneuraminic acid phosphate synthase gene.
The structure of the C-terminal antifreeze-like (AFL) domain of human sialic acid synthase was determined by NMR spectroscopy. The structure comprises one alpha- and two single-turn 3(10)-helices and two beta-strands, and is similar to those of the type III antifreeze proteins. Evolutionary trace analyses of the type III antifreeze protein family suggested that the class-specific residues in the human and bacterial AFL domains are important for their substrate binding, while the class-specific residues of the fish antifreeze proteins are gathered on the ice-binding surface.
Solution structure of the antifreeze-like domain of human sialic acid synthase., Hamada T, Ito Y, Abe T, Hayashi F, Guntert P, Inoue M, Kigawa T, Terada T, Shirouzu M, Yoshida M, Tanaka A, Sugano S, Yokoyama S, Hirota H, Protein Sci. 2006 May;15(5):1010-6. Epub 2006 Apr 5. PMID:16597820
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1WVO is a 1 chain structure of sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Hamada T, Ito Y, Abe T, Hayashi F, Guntert P, Inoue M, Kigawa T, Terada T, Shirouzu M, Yoshida M, Tanaka A, Sugano S, Yokoyama S, Hirota H. Solution structure of the antifreeze-like domain of human sialic acid synthase. Protein Sci. 2006 May;15(5):1010-6. Epub 2006 Apr 5. PMID:16597820 doi:10.1110/ps.051700406
Page seeded by OCA on Tue Feb 17 10:03:57 2009
Categories: Homo sapiens | Hamada, T. | Hayashi, F. | Hirota, H. | Ito, Y. | RSGI, RIKEN Structural Genomics/Proteomics Initiative. | Yokoyama, S. | Antifreeze protein like domain | N-acetylneuraminic acid phosphate synthase | National project on protein structural and functional analyse | Nmr | Nppsfa | Riken structural genomics/proteomics initiative | Rsgi | Structural genomic
