1wjn

Structural highlights

Function

[TBCE_MOUSE] Tubulin-folding protein; involved in the second step of the tubulin folding pathway. Seems to be implicated in the maintenance of the neuronal microtubule network. Involved in regulation of tubulin heterodimer dissociation.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Martin N, Jaubert J, Gounon P, Salido E, Haase G, Szatanik M, Guenet JL. A missense mutation in Tbce causes progressive motor neuronopathy in mice. Nat Genet. 2002 Nov;32(3):443-7. Epub 2002 Oct 21. PMID:12389029 doi:http://dx.doi.org/10.1038/ng1016
2. ↑ Kortazar D, Fanarraga ML, Carranza G, Bellido J, Villegas JC, Avila J, Zabala JC. Role of cofactors B (TBCB) and E (TBCE) in tubulin heterodimer dissociation. Exp Cell Res. 2007 Feb 1;313(3):425-36. Epub 2006 Sep 9. PMID:17184771 doi:http://dx.doi.org/10.1016/j.yexcr.2006.09.002