1whd

Structural highlights

Function

[RGS3_MOUSE] Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Regulator of G-protein signaling 3D structures

References

1. ↑ Lu Q, Sun EE, Klein RS, Flanagan JG. Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction. Cell. 2001 Apr 6;105(1):69-79. PMID:11301003
2. ↑ Hirabayashi S, Ohno H, Iida J, Hata Y. C2PA is a nuclear protein implicated in the heat shock response. J Cell Biochem. 2002;87(1):65-74. PMID:12210723 doi:http://dx.doi.org/10.1002/jcb.10279