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1w45
From Proteopedia
| 1w45, resolution 2.51Å () | |||||||||
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| Related: | 1w3w | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
THE 2.5 ANGSTROEM STRUCTURE OF THE K16A MUTANT OF ANNEXIN A8, WHICH HAS AN INTACT N-TERMINUS.
Annexin A8 is a relatively infrequent and poorly studied member of this large family of calcium-binding and membrane-binding proteins. It is, however, associated with a specific disease, acute promyelocytic leukemia. We have solved its three-dimensional structure, which includes a moderately long and intact N terminus. The structure is closest to that of annexin A3 and highlights several important regions of inherent flexibility in the annexin molecule. The N terminus resembles that of annexin A3, as it lies along the concave surface of the molecule and inserts partially into the hydrophilic channel in its centre. Since both annexins A3 and A8 are expressed in promyelocytic cells during their differentiation, the similarity in their structures might suggest a functional relationship.
The crystal structure of annexin A8 is similar to that of annexin A3., Rety S, Sopkova-de Oliveira Santos J, Dreyfuss L, Blondeau K, Hofbauerova K, Raguenes-Nicol C, Kerboeuf D, Renouard M, Russo-Marie F, Lewit-Bentley A, J Mol Biol. 2005 Feb 4;345(5):1131-9. Epub 2004 Dec 8. PMID:15644210
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1w45 is a 2 chain structure of Annexin with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Rety S, Sopkova-de Oliveira Santos J, Dreyfuss L, Blondeau K, Hofbauerova K, Raguenes-Nicol C, Kerboeuf D, Renouard M, Russo-Marie F, Lewit-Bentley A. The crystal structure of annexin A8 is similar to that of annexin A3. J Mol Biol. 2005 Feb 4;345(5):1131-9. Epub 2004 Dec 8. PMID:15644210 doi:10.1016/j.jmb.2004.11.015
Categories: Homo sapiens | Blondeau, K. | Dreyfuss, L. | Hofbauerova, K. | Lewit-Bentley, A. | Raguenes-Nicol, C. | Renouard, M. | Rety, S. | Russo-Marie, F. | Santos, J Sopkova-De Oliveira. | Annexin family | Calcium and phospholipid binding protein | Coagulation | Cxalcium and membrane- binding protein | Intact n-terminus
