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1utc
From Proteopedia
CLATHRIN TERMINAL DOMAIN COMPLEXED WITH TLPWDLWTT
During the assembly of clathrin-coated vesicles, many peripheral membrane proteins, including the amphiphysins, use LLDLD-type clathrin-box motifs to interact with the N-terminal beta-propeller domain (TD) of clathrin. The 2.3 A-resolution structure of the clathrin TD in complex with a TLPWDLWTT peptide from amphiphysin 1 delineates a second clathrin-binding motif, PWXXW (the W box), that binds at a site on the TD remote from the clathrin box-binding site. The presence of both sequence motifs within the unstructured region of the amphiphysins allows them to bind more tightly to free TDs than do other endocytic proteins that contain only clathrin-box motifs. This property, along with the propensity of the N-terminal BAR domain to bind curved membranes, will preferentially localize amphiphysin and its partner, dynamin, to the periphery of invaginated clathrin lattices.
Two distinct interaction motifs in amphiphysin bind two independent sites on the clathrin terminal domain beta-propeller., Miele AE, Watson PJ, Evans PR, Traub LM, Owen DJ, Nat Struct Mol Biol. 2004 Mar;11(3):242-8. Epub 2004 Feb 15. PMID:14981508
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1UTC is a 4 chains structure of sequences from Bos taurus. Full crystallographic information is available from OCA.
Reference
- Miele AE, Watson PJ, Evans PR, Traub LM, Owen DJ. Two distinct interaction motifs in amphiphysin bind two independent sites on the clathrin terminal domain beta-propeller. Nat Struct Mol Biol. 2004 Mar;11(3):242-8. Epub 2004 Feb 15. PMID:14981508 doi:10.1038/nsmb736
Page seeded by OCA on Wed Feb 18 06:51:57 2009
