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1umr
From Proteopedia
| 1umr, resolution 2.40Å () | |||||||||
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| Related: | 1c3a | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
CRYSTAL STRUCTURE OF THE PLATELET ACTIVATOR CONVULXIN, A DISULFIDE LINKED A4B4 CYCLIC TETRAMER FROM THE VENOM OF CROTALUS DURISSUS TERRIFICUS
Convulxin (CVX), a C-type lectin, isolated from the venom of the South American rattlesnake Crotalus durissus terrificus, causes cardiovascular and respiratory disturbances and is a potent platelet activator which binds to platelet glycoprotein GPVI. The structure of CVX has been solved at 2.4A resolution to a crystallographic residual of 18.6% (R(free)=26.4%). CVX is a disulfide linked heterodimer consisting of homologous alpha and beta chains. The heterodimers are additionally linked by disulfide bridges to form cyclic alpha(4)beta(4)heterotetramers. These domains exhibit significant homology to the carbohydrate-binding domains of C-type lectins, to the factor IX-binding protein (IX-bp), and to flavocetin-A (Fl-A) but sequence and structural differences are observed in both the domains in the putative Ca(2+)and carbohydrate binding regions.
Crystal structure of the platelet activator convulxin, a disulfide-linked alpha4beta4 cyclic tetramer from the venom of Crotalus durissus terrificus., Murakami MT, Zela SP, Gava LM, Michelan-Duarte S, Cintra AC, Arni RK, Biochem Biophys Res Commun. 2003 Oct 17;310(2):478-82. PMID:14521935
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1umr is a 4 chain structure with sequence from Crotalus durissus terrificus. Full crystallographic information is available from OCA.
Reference
- Murakami MT, Zela SP, Gava LM, Michelan-Duarte S, Cintra AC, Arni RK. Crystal structure of the platelet activator convulxin, a disulfide-linked alpha4beta4 cyclic tetramer from the venom of Crotalus durissus terrificus. Biochem Biophys Res Commun. 2003 Oct 17;310(2):478-82. PMID:14521935
- Murakami MT, Watanabe L, Gava LM, Zela SP, Cintra AC, Arni RK. Initial structural analysis of an alpha4beta4 C-type lectin from the venom of Crotalus durissus terrificus. Acta Crystallogr D Biol Crystallogr. 2003 Oct;59(Pt 10):1813-5. Epub 2003, Sep 19. PMID:14501123
