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|1ua7, resolution 2.21Å ()|
|Ligands:||, , , , ,|
Crystal Structure Analysis of Alpha-Amylase from Bacillus Subtilis complexed with Acarbose
The crystal structure of Bacillus subtilis alpha-amylase, in complex with the pseudotetrasaccharide inhibitor acarbose, revealed an hexasaccharide in the active site as a result of transglycosylation. After comparison with the known structure of the catalytic-site mutant complexed with the native substrate maltopentaose, it is suggested that the present structure represents a mimic intermediate in the initial stage of the catalytic process.
Crystal structure of Bacillus subtilis alpha-amylase in complex with acarbose., Kagawa M, Fujimoto Z, Momma M, Takase K, Mizuno H, J Bacteriol. 2003 Dec;185(23):6981-4. PMID:14617662
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
- Kagawa M, Fujimoto Z, Momma M, Takase K, Mizuno H. Crystal structure of Bacillus subtilis alpha-amylase in complex with acarbose. J Bacteriol. 2003 Dec;185(23):6981-4. PMID:14617662