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1u35
From Proteopedia
| 1u35, resolution 3.00Å () | |||||||||||
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| Gene: | H3FA, H3FC, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL (Mus musculus) | ||||||||||
| Domains: | H2A, H4, H3, H2B | ||||||||||
| Related: | 1aoi, 1f66 | ||||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||
Crystal structure of the nucleosome core particle containing the histone domain of macroH2A
macroH2A is an H2A variant with a highly unusual structural organization. It has a C-terminal domain connected to the N-terminal histone domain by a linker. Crystallographic and biochemical studies show that changes in the L1 loop in the histone fold region of macroH2A impact the structure and potentially the function of nucleosomes. The 1.6-A X-ray structure of the nonhistone region reveals an alpha/beta fold which has previously been found in a functionally diverse group of proteins. This region associates with histone deacetylases and affects the acetylation status of nucleosomes containing macroH2A. Thus, the unusual domain structure of macroH2A integrates independent functions that are instrumental in establishing a structurally and functionally unique chromatin domain.
Structural characterization of the histone variant macroH2A., Chakravarthy S, Gundimella SK, Caron C, Perche PY, Pehrson JR, Khochbin S, Luger K, Mol Cell Biol. 2005 Sep;25(17):7616-24. PMID:16107708
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1U35 is a 10 chains structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
- Chakravarthy S, Gundimella SK, Caron C, Perche PY, Pehrson JR, Khochbin S, Luger K. Structural characterization of the histone variant macroH2A. Mol Cell Biol. 2005 Sep;25(17):7616-24. PMID:16107708 doi:25/17/7616
Page seeded by OCA on Tue Feb 17 07:12:36 2009
