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1tou
From Proteopedia
| 1tou, resolution 2.00Å () | |||||||||
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| Ligands: | |||||||||
| Domains: | Lipocalin | ||||||||
| Related: | 1tow | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand
The synthesis and biological evaluation of novel human A-FABP inhibitors based on the 6-(trifluoromethyl)pyrimidine-4(1H)-one scaffold is described. Two series of compounds, bearing either an amino or carbon substituent in the 2-position of the pyrimidine ring were investigated. Modification of substituents and chain length optimization led to novel compounds with low micromolar activity and good selectivity for human A-FABP.
Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors., Ringom R, Axen E, Uppenberg J, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4449-52. PMID:15357970
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1TOU is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Ringom R, Axen E, Uppenberg J, Lundback T, Rondahl L, Barf T. Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4449-52. PMID:15357970 doi:10.1016/j.bmcl.2004.06.058
Page seeded by OCA on Tue Feb 17 00:48:22 2009
