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1sd5
From Proteopedia
| 1sd5, resolution 1.68Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Ligands: | |||||||||
| Gene: | rv1626 (Mycobacterium tuberculosis H37Rv) | ||||||||
| Domains: | ANTAR, REC, AmiR | ||||||||
| Related: | 1s8n | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB, TOPSAN | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Crystal structure of Rv1626
We describe the crystal structure of Rv1626 from Mycobacterium tuberculosis at 1.48 A resolution and the corresponding solution structure determined from small angle X-ray scattering. The N-terminal domain shows structural homology to the receiver domains found in bacterial two-component systems. The C-terminal domain has high structural homology to a recently discovered RNA binding domain involved in transcriptional antitermination. The molecule in solution was found to be monomeric as it is in the crystal, but in solution it undergoes a conformational change that is triggered by changes in ionic strength. This is the first structure that links the phosphorylation cascade of the two-component systems with the antitermination event in the transcriptional machinery. Rv1626 belongs to a family of proteins, which we propose calling phosphorylation-dependent transcriptional antitermination regulators, so far only found in bacteria, and includes NasT, a protein from the assimilatory nitrate/nitrite reductase operon of Azetobacter vinelandii.
The crystal and solution structure of a putative transcriptional antiterminator from Mycobacterium tuberculosis., Morth JP, Feng V, Perry LJ, Svergun DI, Tucker PA, Structure. 2004 Sep;12(9):1595-605. PMID:15341725
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1SD5 is a 1 chain structure of sequence from Mycobacterium tuberculosis h37rv. Full crystallographic information is available from OCA.
Reference
- Morth JP, Feng V, Perry LJ, Svergun DI, Tucker PA. The crystal and solution structure of a putative transcriptional antiterminator from Mycobacterium tuberculosis. Structure. 2004 Sep;12(9):1595-605. PMID:15341725
Page seeded by OCA on Mon Feb 16 12:15:29 2009
Categories: Mycobacterium tuberculosis h37rv | Feng, V. | Morth, J P. | Perry, L J. | Svergun, D I. | TBSGC, TB Structural Genomics Consortium. | Tucker, P A. | Antiterminator | Protein structure initiative | Psi | Rv1626 | Structural genomic | Tb structural genomics consortium | Tbsgc | Transcriptional | Two components system
