Structural highlights
Function
P19_CIRV Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Binds to short interfering RNAs (siRNAs) with high affinity. Acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA.[1] [2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
See Also
References
- ↑ Vargason JM, Szittya G, Burgyan J, Tanaka Hall TM. Size selective recognition of siRNA by an RNA silencing suppressor. Cell. 2003 Dec 26;115(7):799-811. PMID:14697199
- ↑ Xia Z, Zhu Z, Zhu J, Zhou R. Recognition mechanism of siRNA by viral p19 suppressor of RNA silencing: a molecular dynamics study. Biophys J. 2009 Mar 4;96(5):1761-9. doi: 10.1016/j.bpj.2008.11.047. PMID:19254536 doi:http://dx.doi.org/10.1016/j.bpj.2008.11.047
