1pzw

Structural highlights

Function

GRAU_DROME Transcription factor essential for the completion of meiosis in oocytes. Grauzone binds to the promoter region of cort via the zf-AD domain and activates cort expression in ovaries.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Chen B, Harms E, Chu T, Henrion G, Strickland S. Completion of meiosis in Drosophila oocytes requires transcriptional control by grauzone, a new zinc finger protein. Development. 2000 Mar;127(6):1243-51. PMID:10683177
2. ↑ Harms E, Chu T, Henrion G, Strickland S. The only function of Grauzone required for Drosophila oocyte meiosis is transcriptional activation of the cortex gene. Genetics. 2000 Aug;155(4):1831-9. PMID:10924478