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1o0l
From Proteopedia
| 1o0l, 20 NMR models () | |||||||||
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| Gene: | BCL2L2 OR BCLW OR KIAA0271 (Homo sapiens) | ||||||||
| Domains: | BH4, Bcl-2 | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
THE STRUCTURE OF BCL-W REVEALS A ROLE FOR THE C-TERMINAL RESIDUES IN MODULATING BIOLOGICAL ACTIVITY
Pro-survival Bcl-2-related proteins, critical regulators of apoptosis, contain a hydrophobic groove targeted for binding by the BH3 domain of the pro-apoptotic BH3-only proteins. The solution structure of the pro-survival protein Bcl-w, presented here, reveals that the binding groove is not freely accessible as predicted by previous structures of pro-survival Bcl-2-like molecules. Unexpectedly, the groove appears to be occluded by the C-terminal residues. Binding and kinetic data suggest that the C-terminal residues of Bcl-w and Bcl-x(L) modulate pro-survival activity by regulating ligand access to the groove. Binding of the BH3-only proteins, critical for cell death initiation, is likely to displace the hydrophobic C-terminal region of Bcl-w and Bcl-x(L). Moreover, Bcl-w does not act only by sequestering the BH3-only proteins. There fore, pro-survival Bcl-2-like molecules probably control the activation of downstream effectors by a mechanism that remains to be elucidated.
The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity., Hinds MG, Lackmann M, Skea GL, Harrison PJ, Huang DC, Day CL, EMBO J. 2003 Apr 1;22(7):1497-507. PMID:12660157
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1O0L is a 1 chain structure of sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Hinds MG, Lackmann M, Skea GL, Harrison PJ, Huang DC, Day CL. The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity. EMBO J. 2003 Apr 1;22(7):1497-507. PMID:12660157 doi:10.1093/emboj/cdg144
Page seeded by OCA on Tue Feb 17 13:06:53 2009
Categories: Homo sapiens | Day, C L. | Harrison, P J. | Hinds, M G. | Huang, D C.S. | Lackmann, M. | Skea, G L. | Apoptosis | Bcl-2 | Bh3 | Binding groove | Helical bundle
