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1nfi

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This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

1nfi, resolution 2.70Å ()

Domains:

IPT_NFkappaB, RHD, ANK

Structural annotation:
Resources:	CATH : 1Nfib00, 1Nfid00, 1Nfie00, 1Nfif00 InterPro : Ipr008967, Ipr011539, Ipr014756, Ipr002909, Ipr000451, Ipr013783, Ipr011029, Ipr000488, Ipr002110, Ipr015681 Pfam : PF01833, PF00554, PF00023 SCOP : d1nfia2, d1nfia1, d1nfib_, d1nfic1, d1nfic2, d1nfid_, d1nfie_, d1nfif_ UniProt : Q04206, P19838, P25963

Functional annotation:
Resources:	GeneCard : RELA, NFKB1, NFKBIA
Cellular component:	cytoplasm transcription factor complex nucleus cytosol
Biological process:	hair follicle development response to UV-B negative regulation of protein catabolic process response to organic substance cytokine and chemokine mediated signaling pathway cellular defense response inflammatory response positive regulation of transcription, DNA-dependent defense response to virus positive regulation of interleukin-12 biosynthetic process activation of NF-kappaB transcription factor defense response anti-apoptosis regulation of transcription regulation of transcription, DNA-dependent transcription positive regulation of I-kappaB kinase/NF-kappaB cascade organ morphogenesis signal transduction negative regulation of interleukin-12 biosynthetic process apoptosis positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription transcription from RNA polymerase II promoter negative regulation of transcription, DNA-dependent negative regulation of DNA binding regulation of NF-kappaB import into nucleus lipopolysaccharide-mediated signaling pathway negative regulation of myeloid cell differentiation cytoplasmic sequestering of NF-kappaB regulation of cell proliferation negative regulation of Notch signaling pathway cytoplasmic sequestering of transcription factor response to lipopolysaccharide response to exogenous dsRNA protein import into nucleus, translocation
Molecular function:	protein N-terminus binding identical protein binding DNA binding protein kinase activity NF-kappaB binding phosphate binding RNA polymerase II transcription factor activity, enhancer binding transcription factor activity protein binding signal transducer activity transcription factor binding protein kinase binding specific transcriptional repressor activity nuclear localization sequence binding ubiquitin protein ligase binding

Evolutionary conservation:

Toggle Conservation Colors:

Rows = identical sequences:

Further Information:

Caveats,

Explanation,
Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

I-KAPPA-B-ALPHA/NF-KAPPA-B COMPLEX

Publication Abstract from PubMed

The inhibitory protein, IkappaBalpha, sequesters the transcription factor, NF-kappaB, as an inactive complex in the cytoplasm. The structure of the IkappaBalpha ankyrin repeat domain, bound to a partially truncated NF-kappaB heterodimer (p50/ p65), has been determined by X-ray crystallography at 2.7 A resolution. It shows a stack of six IkappaBalpha ankyrin repeats facing the C-terminal domains of the NF-kappaB Rel homology regions. Contacts occur in discontinuous patches, suggesting a combinatorial quality for ankyrin repeat specificity. The first two repeats cover an alpha helically ordered segment containing the p65 nuclear localization signal. The position of the sixth ankyrin repeat shows that full-length IkappaBalpha will occlude the NF-kappaB DNA-binding cleft. The orientation of IkappaBalpha in the complex places its N- and C-terminal regions in appropriate locations for their known regulatory functions.

Structure of an IkappaBalpha/NF-kappaB complex., Jacobs MD, Harrison SC, Cell. 1998 Dec 11;95(6):749-58. PMID:9865693

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1NFI is a 6 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Jacobs MD, Harrison SC. Structure of an IkappaBalpha/NF-kappaB complex. Cell. 1998 Dec 11;95(6):749-58. PMID:9865693

Page seeded by OCA on Wed Feb 18 05:08:30 2009

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Retrieved from "http://www.proteopedia.org/wiki/index.php/1nfi"

Categories: Homo sapiens | Harrison, S C. | Jacobs, M D. | Ankyrin repeat

1nfi

From Proteopedia

I-KAPPA-B-ALPHA/NF-KAPPA-B COMPLEX

About this Structure

Reference

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