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1n5o

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This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

1n5o, resolution 2.80Å ()

Ligands:

Gene:

BRCA1 (Homo sapiens)

Domains:

BRCT

Related:

1jnx

Structural annotation:
Resources:	CATH : 1N5Ox01, 1N5Ox02 InterPro : Ipr011364, Ipr002378, Ipr013083, Ipr001841, Ipr001357 Pfam : PF00533 SCOP : d1n5ox2, d1n5ox1 UniProt : P38398

Functional annotation:
Resources:	GeneCard : BRCA1
Cellular component:	nucleus gamma-tubulin ring complex intracellular protein complex ubiquitin ligase complex BRCA1-BARD1 complex
Biological process:	postreplication repair negative regulation of centriole replication DNA damage response, signal transduction resulting in induction of apoptosis chromosome segregation response to estrogen stimulus negative regulation of fatty acid biosynthetic process lipid biosynthetic process double-strand break repair via homologous recombination DNA repair fatty acid biosynthetic process positive regulation of protein ubiquitination negative regulation of cell cycle regulation of cell proliferation regulation of transcription from RNA polymerase II promoter response to DNA damage stimulus regulation of transcription from RNA polymerase III promoter protein ubiquitination regulation of apoptosis positive regulation of DNA repair cell cycle DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator apoptosis positive regulation of transcription, DNA-dependent regulation of DNA repair androgen receptor signaling pathway negative regulation of transcription
Molecular function:	zinc ion binding androgen receptor binding DNA binding enzyme binding ubiquitin-protein ligase activity tubulin binding transcription coactivator activity transcription activator activity protein binding metal ion binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

1 Structural consequences of a cancer-causing BRCA1-BRCT missense mutation
2 Disease
3 About this Structure
4 Reference

Structural consequences of a cancer-causing BRCA1-BRCT missense mutation

Publication Abstract from PubMed

The integrity of the carboxyl-terminal BRCT repeat region is critical for BRCA1 tumor suppressor function; however, the molecular details of how a number of clinically derived BRCT missense mutations affect BRCA1 function remain largely unknown. Here we assess the structural response of the BRCT tandem repeat domain to a well characterized, cancer-associated single amino acid substitution, Met-1775 --> Arg-1775. The structure of BRCT-M1775R reveals that the mutated side chain is extruded from the protein hydrophobic core, thereby altering the protein surface. Charge-charge repulsion, rearrangement of the hydrophobic core, and disruption of the native hydrogen bonding network at the interface between the two BRCT repeats contribute to the conformational instability of BRCT-M1775R. Destabilization and global unfolding of the mutated BRCT domain at physiological temperatures explain the pleiotropic molecular and genetic defects associated with the BRCA1-M1775R protein.

Structural consequences of a cancer-causing BRCA1-BRCT missense mutation., Williams RS, Glover JN, J Biol Chem. 2003 Jan 24;278(4):2630-5. Epub 2002 Nov 8. PMID:12427738

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Disease

Known disease associated with this structure: Breast cancer-1 OMIM:[113705], Breast-ovarian cancer OMIM:[113705], Ovarian cancer OMIM:[113705], Papillary serous carcinoma of the peritoneum OMIM:[113705]

About this Structure

1N5O is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Williams RS, Glover JN. Structural consequences of a cancer-causing BRCA1-BRCT missense mutation. J Biol Chem. 2003 Jan 24;278(4):2630-5. Epub 2002 Nov 8. PMID:12427738 doi:10.1074/jbc.M210019200

Page seeded by OCA on Wed Feb 18 00:06:44 2009

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1n5o

From Proteopedia

Contents

Structural consequences of a cancer-causing BRCA1-BRCT missense mutation

Disease

About this Structure

Reference

Proteopedia Page Contributors and Editors (what is this?)

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