1myo

Structural highlights

Function

MTPN_RAT Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity). Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Knuefermann P, Shi SP, Chen P, Sakata Y, Baumgarten G, Sivasubramanian N. Myotrophin/V-1 does not act as an extracellular signal to induce myocyte hypertrophy. Tex Heart Inst J. 2006;33(3):281-9. PMID:17041682
2. ↑ Das B, Gupta S, Vasanji A, Xu Z, Misra S, Sen S. Nuclear co-translocation of myotrophin and p65 stimulates myocyte growth. Regulation by myotrophin hairpin loops. J Biol Chem. 2008 Oct 10;283(41):27947-56. doi: 10.1074/jbc.M801210200. Epub 2008, Aug 7. PMID:18693253 doi:http://dx.doi.org/10.1074/jbc.M801210200