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1mnm
From Proteopedia
| 1mnm, resolution 2.25Å () | |||||||||
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| Domains: | homeodomain, MADS_MEF2_like | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
YEAST MATALPHA2/MCM1/DNA TERNARY TRANSCRIPTION COMPLEX CRYSTAL STRUCTURE
The structure of a complex containing the homeodomain repressor protein MATalpha2 and the MADS-box transcription factor MCM1 bound to DNA has been determined by X-ray crystallography at 2.25 A resolution. It reveals the protein-protein interactions responsible for cooperative binding of MATalpha2 and MCM1 to DNA. The otherwise flexible amino-terminal extension of the MATalpha2 homeodomain forms a beta-hairpin that grips the MCM1 surface through parallel beta-strand hydrogen bonds and close-packed, predominantly hydrophobic, side chains. DNA bending induced by MCM1 brings the two proteins closer together, facilitating their interaction. An unusual feature of the complex is that an eight-amino-acid sequence adopts an alpha-helical conformation in one of two copies of the MATalpha2 monomer and a beta-strand conformation in the other. This 'chameleon' sequence of MATalpha2 may be important for recognizing natural operator sites.
Crystal structure of the yeast MATalpha2/MCM1/DNA ternary complex., Tan S, Richmond TJ, Nature. 1998 Feb 12;391(6668):660-6. PMID:9490409
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1MNM is a 6 chains structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
- Tan S, Richmond TJ. Crystal structure of the yeast MATalpha2/MCM1/DNA ternary complex. Nature. 1998 Feb 12;391(6668):660-6. PMID:9490409 doi:10.1038/35563
Page seeded by OCA on Wed Feb 18 06:00:39 2009
