First time at Proteopedia? Click on the green links: they change the 3D image. Click and drag the molecules. Proteopedia is a 3D, interactive encyclopedia of proteins, RNA, DNA and other molecules. With a free user account, you can edit pages in Proteopedia. Visit the Main Page to learn more.
1mhe
From Proteopedia
| 1mhe, resolution 2.85Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Ligands: | |||||||||
| Gene: | HLA-E (Homo sapiens), BETA-2-MICROGLOBULIN (Homo sapiens) | ||||||||
| Domains: | IGc, MHC_I | ||||||||
| |||||||||
| |||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
THE HUMAN NON-CLASSICAL MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE HLA-E
The crystal structure of the nonclassical human class lb MHC molecule HLA-E has been determined in complex with a prototypic ligand, the nonamer peptide (VMAPRTVLL), derived from the highly conserved residues 3-11 of the human MHC class la leader sequence. The mode of peptide binding retains some of the standard features observed in MHC class la complexes, but novel features imply that HLA-E has evolved to mediate specific binding to a tightly defined set of almost identical hydrophobic peptides from the highly conserved class l leader sequences. These molecular adaptations make HLA-E a rigorous checkpoint at the cell surface reporting on the integrity of the antigen processing pathway to CD94/NKG2 receptor-bearing natural killer cells.
Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E., O'Callaghan CA, Tormo J, Willcox BE, Braud VM, Jakobsen BK, Stuart DI, McMichael AJ, Bell JI, Jones EY, Mol Cell. 1998 Mar;1(4):531-41. PMID:9660937
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1MHE is a 6 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- O'Callaghan CA, Tormo J, Willcox BE, Braud VM, Jakobsen BK, Stuart DI, McMichael AJ, Bell JI, Jones EY. Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E. Mol Cell. 1998 Mar;1(4):531-41. PMID:9660937
Page seeded by OCA on Wed Feb 18 00:18:52 2009
Categories: Homo sapiens | Bell, J I. | Braud, V B. | Callaghan, C A.O. | Jakobsen, B K. | Jones, E Y. | Mcmichael, A J. | Stuart, D I. | Tormo, J. | Willcox, B E. | Beta 2 microglobulin | Class ib mhc | Hla | Hla e | Hla-e | Leader peptide | Major histocompatibility complex | Mhc | Non-classical mhc | Peptide
