1lvb

Structural highlights

Function

POLG_TEV Capsid protein: involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.^{[1] [2]} Nuclear inclusion protein B: an RNA-dependent RNA polymerase that plays an essential role in the virus replication.^{[3] [4]} Helper component proteinase: required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity.^{[5] [6]} Cytoplasmic inclusion protein: has helicase activity. It may be involved in replication.^{[7] [8]} Both 6K peptides are indispensable for virus replication (By similarity).^{[9] [10]} Nuclear inclusion protein A: has RNA-binding and proteolytic activities.^{[11] [12]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Tobacco Etch Virus (TEV) Protease

References

1. ↑ Blanc S, Ammar ED, Garcia-Lampasona S, Dolja VV, Llave C, Baker J, Pirone TP. Mutations in the potyvirus helper component protein: effects on interactions with virions and aphid stylets. J Gen Virol. 1998 Dec;79 ( Pt 12):3119-22. PMID:9880030
2. ↑ Kasschau KD, Carrington JC. Long-distance movement and replication maintenance functions correlate with silencing suppression activity of potyviral HC-Pro. Virology. 2001 Jun 20;285(1):71-81. PMID:11414807 doi:http://dx.doi.org/10.1006/viro.2001.0901
3. ↑ Blanc S, Ammar ED, Garcia-Lampasona S, Dolja VV, Llave C, Baker J, Pirone TP. Mutations in the potyvirus helper component protein: effects on interactions with virions and aphid stylets. J Gen Virol. 1998 Dec;79 ( Pt 12):3119-22. PMID:9880030
4. ↑ Kasschau KD, Carrington JC. Long-distance movement and replication maintenance functions correlate with silencing suppression activity of potyviral HC-Pro. Virology. 2001 Jun 20;285(1):71-81. PMID:11414807 doi:http://dx.doi.org/10.1006/viro.2001.0901
5. ↑ Blanc S, Ammar ED, Garcia-Lampasona S, Dolja VV, Llave C, Baker J, Pirone TP. Mutations in the potyvirus helper component protein: effects on interactions with virions and aphid stylets. J Gen Virol. 1998 Dec;79 ( Pt 12):3119-22. PMID:9880030
6. ↑ Kasschau KD, Carrington JC. Long-distance movement and replication maintenance functions correlate with silencing suppression activity of potyviral HC-Pro. Virology. 2001 Jun 20;285(1):71-81. PMID:11414807 doi:http://dx.doi.org/10.1006/viro.2001.0901
7. ↑ Blanc S, Ammar ED, Garcia-Lampasona S, Dolja VV, Llave C, Baker J, Pirone TP. Mutations in the potyvirus helper component protein: effects on interactions with virions and aphid stylets. J Gen Virol. 1998 Dec;79 ( Pt 12):3119-22. PMID:9880030
8. ↑ Kasschau KD, Carrington JC. Long-distance movement and replication maintenance functions correlate with silencing suppression activity of potyviral HC-Pro. Virology. 2001 Jun 20;285(1):71-81. PMID:11414807 doi:http://dx.doi.org/10.1006/viro.2001.0901
9. ↑ Blanc S, Ammar ED, Garcia-Lampasona S, Dolja VV, Llave C, Baker J, Pirone TP. Mutations in the potyvirus helper component protein: effects on interactions with virions and aphid stylets. J Gen Virol. 1998 Dec;79 ( Pt 12):3119-22. PMID:9880030
10. ↑ Kasschau KD, Carrington JC. Long-distance movement and replication maintenance functions correlate with silencing suppression activity of potyviral HC-Pro. Virology. 2001 Jun 20;285(1):71-81. PMID:11414807 doi:http://dx.doi.org/10.1006/viro.2001.0901
11. ↑ Blanc S, Ammar ED, Garcia-Lampasona S, Dolja VV, Llave C, Baker J, Pirone TP. Mutations in the potyvirus helper component protein: effects on interactions with virions and aphid stylets. J Gen Virol. 1998 Dec;79 ( Pt 12):3119-22. PMID:9880030
12. ↑ Kasschau KD, Carrington JC. Long-distance movement and replication maintenance functions correlate with silencing suppression activity of potyviral HC-Pro. Virology. 2001 Jun 20;285(1):71-81. PMID:11414807 doi:http://dx.doi.org/10.1006/viro.2001.0901