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1l8r
From Proteopedia
| 1l8r, resolution 1.65Å () | |||||||||
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| Non-Standard Residues: | |||||||||
| Domains: | Ski_Sno | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Structure of the Retinal Determination Protein Dachshund Reveals a DNA-Binding Motif
The Dachshund proteins are essential components of a regulatory network controlling cell fate determination. They have been implicated in eye, limb, brain, and muscle development. These proteins cannot be assigned to any recognizable structural or functional class based on amino acid sequence analysis. The 1.65 A crystal structure of the most conserved domain of human DACHSHUND is reported here. The protein forms an alpha/beta structure containing a DNA binding motif similar to that found in the winged helix/forkhead subgroup of the helix-turn-helix family. This unexpected finding alters the previously proposed molecular models for the role of Dachshund in the eye determination pathway. Furthermore, it provides a rational framework for future mechanistic analyses of the Dachshund proteins in several developmental contexts.
Structure of the retinal determination protein Dachshund reveals a DNA binding motif., Kim SS, Zhang RG, Braunstein SE, Joachimiak A, Cvekl A, Hegde RS, Structure. 2002 Jun;10(6):787-95. PMID:12057194
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1L8R is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Kim SS, Zhang RG, Braunstein SE, Joachimiak A, Cvekl A, Hegde RS. Structure of the retinal determination protein Dachshund reveals a DNA binding motif. Structure. 2002 Jun;10(6):787-95. PMID:12057194
Page seeded by OCA on Mon Feb 16 18:56:28 2009
