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1kwa
From Proteopedia
| 1kwa, resolution 1.93Å () | |||||||||
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| Ligands: | |||||||||
| Gene: | HCASK (Homo sapiens) | ||||||||
| Domains: | PDZ_signaling | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
HUMAN CASK/LIN-2 PDZ DOMAIN
PDZ domain containing proteins assist formation of cell-cell junctions and localization of membrane protein receptors and ion channels. PDZ domains interact with the C-terminal residues of a particular target membrane protein. Based on their binding specificities and sequence homologies, PDZ domains fall into two classes. The first crystal structure of a class II PDZ domain, that of hCASK, has been solved by multi-wavelength anomalous dispersion phasing. Complex formation with the C-terminus of a neighboring non-crystallographically related PDZ domain reveals interactions between hCASK and its ligand. Class II PDZ domains differ from class I domains by formation of a second hydrophobic binding pocket. The C-terminal carboxylate binding loop of the PDZ domain is structurally conserved in both classes suggesting a generalized carboxylate binding motif (h-Gly-h) where h is a hydrophobic residue.
Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition., Daniels DL, Cohen AR, Anderson JM, Brunger AT, Nat Struct Biol. 1998 Apr;5(4):317-25. PMID:9546224
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1KWA is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Daniels DL, Cohen AR, Anderson JM, Brunger AT. Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition. Nat Struct Biol. 1998 Apr;5(4):317-25. PMID:9546224
Page seeded by OCA on Mon Feb 16 22:14:22 2009
