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1jsu

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This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

1jsu, resolution 2.30Å ()

Ligands:

Non-Standard Residues:

Domains:

S_TKc, S_TKc, CDI, Cyclin_C, CYCLIN

Structural annotation:
Resources:	CATH : 1Jsua02, 1Jsua01, 1Jsub01, 1Jsub02, 1Jsuc00 InterPro : Ipr002290, Ipr011009, Ipr008271, Ipr000719, Ipr006670, Ipr014400, Ipr013763, Ipr015453, Ipr011028, Ipr004367, Ipr006671, Ipr003175, Ipr015456 Pfam : PF00069, PF00134, PF02984, PF02234 SCOP : d1jsua_, d1jsub1, d1jsub2, d1jsuc_ UniProt : P24941, P20248, P46527

Functional annotation:
Resources:	GeneCard : CDK2, CCNA2, CDKN1B
Cellular component:	cytoplasm nucleus male pronucleus female pronucleus cytosol
Biological process:	cell cycle G2/M transition of mitotic cell cycle mitosis cell division traversing start control point of mitotic cell cycle positive regulation of cell proliferation regulation of DNA replication protein amino acid phosphorylation regulation of cyclin-dependent protein kinase activity positive regulation of transcription mitotic cell cycle G2/M transition DNA damage checkpoint sensory perception of sound negative regulation of epithelial cell proliferation negative regulation of cyclin-dependent protein kinase activity positive regulation of microtubule polymerization inner ear development negative regulation of cell motility cell cycle arrest negative regulation of cell proliferation
Molecular function:	kinase activity nucleotide binding protein kinase activity identical protein binding ATP binding transferase activity protein binding cyclin-dependent protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein kinase inhibitor activity protein kinase inhibitor activity transforming growth factor beta receptor, cytoplasmic mediator activity
Subcellular localization (predicted):	nucleus, 1 cytoplasm, 1 not secreted, 6 Explanation Complete Results at PredictProtein

Evolutionary conservation:

Toggle Conservation Colors:

Rows = identical sequences:

Further Information:

Caveats,

Explanation,
Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

P27(KIP1)/CYCLIN A/CDK2 COMPLEX

Publication Abstract from PubMed

The crystal structure of the human p27Kip1 kinase inhibitory domain bound to the phosphorylated cyclin A-cyclin-dependent kinase 2 (Cdk2) complex has been determined at 2.3 angstrom. p27Kip1 binds the complex as an extended structure interacting with both cyclin A and Cdk2. On cyclin A, it binds in a groove formed by conserved cyclin box residues. On Cdk2, it binds and rearranges the amino-terminal lobe and also inserts into the catalytic cleft, mimicking ATP.

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex., Russo AA, Jeffrey PD, Patten AK, Massague J, Pavletich NP, Nature. 1996 Jul 25;382(6589):325-31. PMID:8684460

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1JSU is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Russo AA, Jeffrey PD, Patten AK, Massague J, Pavletich NP. Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature. 1996 Jul 25;382(6589):325-31. PMID:8684460 doi:10.1038/382325a0

Page seeded by OCA on Tue Feb 17 05:54:32 2009

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1jsu

From Proteopedia

P27(KIP1)/CYCLIN A/CDK2 COMPLEX

About this Structure

Reference

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