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1jnx

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This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

1jnx, resolution 2.50Å ()

Ligands:

Gene:

BRCA1 (Homo sapiens)

Domains:

BRCT

Related:

1cdz, 1imo, 1in1

Structural annotation:
Resources:	CATH : 1Jnxx02, 1Jnxx01 InterPro : Ipr013083, Ipr002378, Ipr001841, Ipr011364, Ipr001357 Pfam : PF00533 SCOP : d1jnxx1, d1jnxx2 UniProt : P38398

Functional annotation:
Resources:	GeneCard : BRCA1
Cellular component:	nucleus protein complex gamma-tubulin ring complex intracellular BRCA1-BARD1 complex ubiquitin ligase complex
Biological process:	negative regulation of fatty acid biosynthetic process regulation of cell proliferation regulation of transcription from RNA polymerase II promoter positive regulation of transcription, DNA-dependent cell cycle apoptosis regulation of transcription from RNA polymerase III promoter protein ubiquitination double-strand break repair via homologous recombination DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator negative regulation of transcription chromosome segregation DNA repair response to DNA damage stimulus fatty acid biosynthetic process negative regulation of cell cycle postreplication repair regulation of apoptosis androgen receptor signaling pathway positive regulation of DNA repair response to estrogen stimulus lipid biosynthetic process negative regulation of centriole replication DNA damage response, signal transduction resulting in induction of apoptosis regulation of DNA repair positive regulation of protein ubiquitination
Molecular function:	ubiquitin-protein ligase activity transcription activator activity zinc ion binding transcription coactivator activity enzyme binding tubulin binding androgen receptor binding metal ion binding DNA binding protein binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

1 Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1
2 Disease
3 About this Structure
4 Reference

Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1

Publication Abstract from PubMed

The C-terminal BRCT region of BRCA1 is essential for its DNA repair, transcriptional regulation and tumor suppressor functions. Here we determine the crystal structure of the BRCT domain of human BRCA1 at 2.5 A resolution. The domain contains two BRCT repeats that adopt similar structures and are packed together in a head-to-tail arrangement. Cancer-causing missense mutations occur at the interface between the two repeats and destabilize the structure. The manner by which the two BRCT repeats interact in BRCA1 may represent a general mode of interaction between homologous domains within proteins that interact to regulate the cellular response to DNA damage. The structure provides a basis to predict the structural consequences of uncharacterized BRCA1 mutations.

Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1., Williams RS, Green R, Glover JN, Nat Struct Biol. 2001 Oct;8(10):838-42. PMID:11573086

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Disease

Known disease associated with this structure: Breast cancer-1 OMIM:[113705], Breast-ovarian cancer OMIM:[113705], Ovarian cancer OMIM:[113705], Papillary serous carcinoma of the peritoneum OMIM:[113705]

About this Structure

1JNX is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Williams RS, Green R, Glover JN. Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1. Nat Struct Biol. 2001 Oct;8(10):838-42. PMID:11573086 doi:10.1038/nsb1001-838

Page seeded by OCA on Mon Feb 16 13:12:09 2009

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Retrieved from "http://www.proteopedia.org/wiki/index.php/1jnx"

1jnx

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Contents

Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1

Disease

About this Structure

Reference

Proteopedia Page Contributors and Editors (what is this?)

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