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1ji7
From Proteopedia
| 1ji7, resolution 1.45Å () | |||||||||
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| Ligands: | |||||||||
| Non-Standard Residues: | |||||||||
| Gene: | TEL (Homo sapiens) | ||||||||
| Domains: | SAM_PNT | ||||||||
| Related: | 1bqv | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
Crystal Structure of TEL SAM Polymer
TEL is a transcriptional repressor that is a frequent target of chromosomal translocations in a large number of hematalogical malignancies. These rearrangements fuse a potent oligomerization module, the SAM domain of TEL, to a variety of tyrosine kinases or transcriptional regulatory proteins. The self-associating property of TEL-SAM is essential for cell transformation in many, if not all of these diseases. Here we show that the TEL-SAM domain forms a helical, head-to-tail polymeric structure held together by strong intermolecular contacts, providing the first clear demonstration that SAM domains can polymerize. Our results also suggest a mechanism by which SAM domains could mediate the spreading of transcriptional repression complexes along the chromosome.
Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression., Kim CA, Phillips ML, Kim W, Gingery M, Tran HH, Robinson MA, Faham S, Bowie JU, EMBO J. 2001 Aug 1;20(15):4173-82. PMID:11483520
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Disease
Known disease associated with this structure: Leukemia, acute myeloid, somatic OMIM:[600618]
About this Structure
1JI7 is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Kim CA, Phillips ML, Kim W, Gingery M, Tran HH, Robinson MA, Faham S, Bowie JU. Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression. EMBO J. 2001 Aug 1;20(15):4173-82. PMID:11483520 doi:10.1093/emboj/20.15.4173
Page seeded by OCA on Mon Feb 16 10:40:22 2009
