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1jdh

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1jdh, resolution 1.90Å ()

Structural annotation:
Resources:	CATH : 1Jdha00 InterPro : Ipr000225, Ipr000357, Ipr011989, Ipr013284, Ipr000910, Ipr009071, Ipr013558 Pfam : PF00514, PF02985, PF08347 SCOP : d1jdha_, d1jdhb_ UniProt : P35222, Q9NQB0

Functional annotation:
Cellular component:	lamellipodium cell-cell adherens junction plasma membrane beta-catenin destruction complex adherens junction membrane fraction basolateral plasma membrane intercellular junction cytoskeleton cytoplasm nucleus membrane Z disc transcription factor complex apical part of cell microvillus membrane lateral plasma membrane fascia adherens
Biological process:	endodermal cell fate commitment positive regulation of transcription morphogenesis of embryonic epithelium negative regulation of transcription, DNA-dependent regulation of cell proliferation positive regulation of epithelial cell differentiation cellular process bone resorption hemopoiesis cell maturation Wnt receptor signaling pathway androgen receptor signaling pathway negative regulation of transcription from RNA polymerase II promoter ectoderm development cellular morphogenesis during differentiation synaptic vesicle transport cell-cell adhesion embryonic hindlimb morphogenesis patterning of blood vessels regulation of transcription endoderm formation camera-type eye morphogenesis negative regulation of cell differentiation regulation of transcription, DNA-dependent negative regulation of osteoclast differentiation positive regulation of osteoblast differentiation lung development positive regulation of transcription, DNA-dependent embryonic arm morphogenesis synapse organization and biogenesis positive regulation of transcription from RNA polymerase II promoter embryonic digit morphogenesis proximal/distal pattern formation dorsal/ventral axis specification cell fate determination regulation of osteoblast differentiation regulation of cell differentiation heart development transcription synaptic transmission forebrain development dorsal/ventral pattern formation Wnt receptor signaling pathway through beta-catenin cell differentiation cell fate specification osteoclast differentiation pancreas development odontogenesis of dentine-containing teeth cell adhesion epithelial to mesenchymal transition skeletal development regulation of transcription from RNA polymerase II promoter signal transduction establishment and/or maintenance of chromatin architecture regulation of Wnt receptor signaling pathway
Molecular function:	DNA binding androgen receptor binding binding transcription factor activity alpha-catenin binding transcription coactivator activity protein binding signal transducer activity chromatin binding cadherin binding structural molecule activity protein C-terminus binding RNA polymerase II transcription factor activity

Evolutionary conservation:

Toggle Conservation Colors:

Rows = identical sequences:

Further Information:

Caveats,

Explanation,
Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

1 CRYSTAL STRUCTURE OF BETA-CATENIN AND HTCF-4
2 About this Structure
3 See Also
4 Reference

CRYSTAL STRUCTURE OF BETA-CATENIN AND HTCF-4

Publication Abstract from PubMed

Accumulation of the Wnt pathway effector beta-catenin is a hallmark of a number of cancers, including colon cancer. As beta-catenin accumulates in the cell, it forms a complex with Tcf family transcription factors and activates the transcription of several critical genes involved in cell proliferation. Because Tcf4 is the predominant Tcf factor present in colon cancer cells, drugs that specifically disrupt the beta-catenin-Tcf4 complex could be useful in treating colon cancers. Earlier structural and biochemical studies demonstrated that the central region of the beta-catenin binding domain of Tcf is essential for anchoring Tcf to beta-catenin via two conserved lysines in beta-catenin (called the charged 'buttons'). Here we report the crystal structure of a beta-catenin-Tcf4 complex at 2.0 A resolution. Our structural and mutagenesis studies show that Tcf4 docks specifically to beta-catenin using several distinct conformations in its essential central region. These conformations allow different glutamate residues in the central region of Tcf4 to form a salt bridge with the same critical charged button, Lys 312 of beta-catenin. We propose that this interaction may be the first event in beta-catenin-Tcf4 recognition.

Tcf4 can specifically recognize beta-catenin using alternative conformations., Graham TA, Ferkey DM, Mao F, Kimelman D, Xu W, Nat Struct Biol. 2001 Dec;8(12):1048-52. PMID:11713475

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1jdh is a 2 chain structure of Catenin with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Graham TA, Ferkey DM, Mao F, Kimelman D, Xu W. Tcf4 can specifically recognize beta-catenin using alternative conformations. Nat Struct Biol. 2001 Dec;8(12):1048-52. PMID:11713475 doi:10.1038/nsb718

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1jdh

From Proteopedia

Contents

CRYSTAL STRUCTURE OF BETA-CATENIN AND HTCF-4

About this Structure

See Also

Reference

Proteopedia Page Contributors and Editors (what is this?)

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