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1iv5
From Proteopedia
| 1iv5, resolution 2.60Å () | |||||||||
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| Domains: | CD81_like_LEL | ||||||||
| Related: | 1g8q | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
New Crystal Form of Human CD81 Large Extracellular Loop.
The large extracellular loop of human CD81, a tetraspanin mediating hepatitis C virus envelope protein E2 binding to human cells, has been crystallized in a hexagonal form. The three-dimensional structure, solved and refined at 2.6 A resolution (R-factor = 22.8%), shows that the protein adopts a dimeric assembly, based on an association interface built up by tetraspanin-conserved residues. Structural comparisons with the tertiary structure of human CD81 large extracellular loop, previously determined in a different crystal form, show marked conformational fluctuations in the molecular regions thought to be involved in binding to the viral protein, suggesting rules for recognition and assembly within the tetraspan web.
Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop., Kitadokoro K, Ponassi M, Galli G, Petracca R, Falugi F, Grandi G, Bolognesi M, Biol Chem. 2002 Sep;383(9):1447-52. PMID:12437138
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1IV5 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Kitadokoro K, Ponassi M, Galli G, Petracca R, Falugi F, Grandi G, Bolognesi M. Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop. Biol Chem. 2002 Sep;383(9):1447-52. PMID:12437138
Page seeded by OCA on Mon Feb 16 18:46:07 2009
